According to Joseph Jorizzo, MD, from Wake Forest University, “your skin can be a window to your underlying health.” Skin changes can sometimes be the body’s first warning of deeper issues, making early recognition important.

Livedo reticularis (LR), or mottled skin, appears as a purplish, lace-like pattern, usually on arms or legs. It’s most common in babies and women aged 20–50. The discoloration results from changes in blood flow near the skin, often triggered by cold, stress, or low oxygen. It can also be a side effect of medications like amantadine.

There are two types: Primary LR, a harmless reaction to cold that fades when warmed, and Secondary LR, which is linked to health conditions such as lupus, rheumatoid arthritis, blood clotting issues, thyroid disease, or even septic shock.

Rarely, LR may signal serious illnesses like Sneddon’s syndrome, polyarteritis nodosa, or cholesterol embolization.

Primary LR usually needs no treatment, but secondary cases may require medication, lifestyle changes, and medical care.