Ozempic, originally developed for Type 2 diabetes, has become popular for weight loss by “slowing digestion and extending feelings of fullness.” But alongside benefits, users are reporting unexpected side effects.

Beyond nausea and constipation, women online describe changes nicknamed “Ozempic vulva.” Dr. Tahery, a Los Angeles physician, says possible effects include “sagging of the labia, weakened vaginal muscles, and dryness,” which match many patient stories.

The cause lies in rapid fat loss. Dr. Justin Perron of the Australasian Society of Aesthetic Plastic Surgeons explains, “weight loss affects fat throughout the body,” including tissue in the mons pubis and labia, leading to sagging or volume loss.

Muscle mass may also be reduced. Weakening pelvic muscles can cause structural changes, while gynecologist Dr. Melanie Bone adds that “hormonal shifts and reduced hydration” may increase dryness and discomfort.

Some women seek cosmetic treatments such as dermal fillers for “genital rejuvenation.” While not everyone experiences these effects, the growing reports stress the need for more research into Ozempic’s full impact beyond weight loss.